{"symbol":"PRDM2","synonyms":["RIZ1","RIZ","HUMHOXY1","RIZ2","MTB-ZF","KMT8","KMT8A"],"name":"PR domain containing 2, with ZNF domain","description":"This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]","ncbiEntrezGeneId":7799,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/7799","proteins":[{"symbol":"PRDM2_HUMAN","href":"/api/1.0/protein/PRDM2_HUMAN"}],"hgncRootFamilies":[{"name":"Chromatin-modifying enzymes","href":"/api/1.0/gene_family/Chromatin-modifying+enzymes"}]}