{"symbol":"PRDM9","synonyms":["MSBP3","PRMD9","MEISETZ","KMT8B","PFM6","ZNF899"],"name":"PR domain containing 9","description":"The protein encoded by this gene is a zinc finger protein with histone methyltransferase activity that catalyzes histone H3 lysine 4 trimethylation (H3K4me3) during meiotic prophase. This protein contains multiple domains, including a Kruppel-associated box (KRAB) domain, an SSX repression domain (SSXRD), a PRD1-BF1 and RIZ homologous region, a subclass of SET (PR/SET) domain, and a tandem array of C2H2 zinc fingers. The zinc finger array recognizes a short sequence motif, leading to local H3K4me3, and meiotic recombination hotspot activity. The observed allelic variation alters the DNA-binding sequence specificity of the protein, resulting in distinct meiotic recombination hotspots amongst individuals and populations. Multiple alternate alleles of this gene have been described. [provided by RefSeq, Jul 2015]","ncbiEntrezGeneId":56979,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/56979","proteins":[{"symbol":"PRDM9_HUMAN","href":"/api/1.0/protein/PRDM9_HUMAN"}],"hgncRootFamilies":[{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}