{"symbol":"PRICKLE1","synonyms":["EPM1B","RILP"],"name":"prickle homolog 1 (Drosophila)","description":"This gene encodes a nuclear receptor that may be a negative regulator of the Wnt/beta-catenin signaling pathway. The encoded protein localizes to the nuclear membrane and has been implicated in the nuclear trafficking of the transcription repressors REST/NRSF and REST4. Mutations in this gene have been linked to progressive myoclonus epilepsy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3. [provided by RefSeq, Sep 2009]","ncbiEntrezGeneId":144165,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/144165","proteins":[{"symbol":"PRIC1_HUMAN","href":"/api/1.0/protein/PRIC1_HUMAN"}],"hgncRootFamilies":[]}