{"symbol":"PRKAA1","synonyms":["AMPK","AMPKA1"],"name":"protein kinase, AMP-activated, alpha 1 catalytic subunit","description":"The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5\u0027-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":5562,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5562","proteins":[{"symbol":"AAPK1_HUMAN","href":"/api/1.0/protein/AAPK1_HUMAN"}],"hgncRootFamilies":[]}