{"symbol":"PRKAB2","synonyms":[],"name":"protein kinase, AMP-activated, beta 2 non-catalytic subunit","description":"The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. It is highly expressed in skeletal muscle and thus may have tissue-specific roles. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2013]","ncbiEntrezGeneId":5565,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5565","proteins":[{"symbol":"AAKB2_HUMAN","href":"/api/1.0/protein/AAKB2_HUMAN"}],"hgncRootFamilies":[]}