{"symbol":"PRKAG2","synonyms":["AAKG2","CMH6","H91620P","AAKG","WPWS"],"name":"protein kinase, AMP-activated, gamma 2 non-catalytic subunit","description":"AMP-activated protein kinase (AMPK) is a heterotrimeric protein composed of a catalytic alpha subunit, a noncatalytic beta subunit, and a noncatalytic regulatory gamma subunit. Various forms of each of these subunits exist, encoded by different genes. AMPK is an important energy-sensing enzyme that monitors cellular energy status and functions by inactivating key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This gene is a member of the AMPK gamma subunit family. Mutations in this gene have been associated with Wolff-Parkinson-White syndrome, familial hypertrophic cardiomyopathy, and glycogen storage disease of the heart. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jan 2015]","ncbiEntrezGeneId":51422,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/51422","proteins":[{"symbol":"AAKG2_HUMAN","href":"/api/1.0/protein/AAKG2_HUMAN"}],"hgncRootFamilies":[]}