{"symbol":"PRKCQ","synonyms":["NPKC-THETA","PRKCT"],"name":"protein kinase C, theta","description":"Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipid-dependent protein kinase. This kinase is important for T-cell activation. It is required for the activation of the transcription factors NF-kappaB and AP-1, and may link the T cell receptor (TCR) signaling complex to the activation of the transcription factors. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":5588,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5588","proteins":[{"symbol":"KPCT_HUMAN","href":"/api/1.0/protein/KPCT_HUMAN"}],"hgncRootFamilies":[{"name":"C2 domain containing","href":"/api/1.0/gene_family/C2+domain+containing"}]}