{"symbol":"PRKD3","synonyms":["PKC-NU","EPK2","NPKC-NU","PKD3","PRKCN"],"name":"protein kinase D3","description":"This gene belongs to the multigene protein kinase D family of serine/threonine kinases, which bind diacylglycerol and phorbol esters. Members of this family are characterized by an N-terminal regulatory domain comprised of a tandem repeat of cysteine-rich zinc-finger motifs and a pleckstrin domain. The C-terminal region contains the catalytic domain and is distantly related to calcium-regulated kinases. Catalytic activity of this enzyme promotes its nuclear localization. This protein has been implicated in a variety of functions including negative regulation of human airway epithelial barrier formation, growth regulation of breast and prostate cancer cells, and vesicle trafficking. [provided by RefSeq, Jan 2015]","ncbiEntrezGeneId":23683,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/23683","proteins":[{"symbol":"KPCD3_HUMAN","href":"/api/1.0/protein/KPCD3_HUMAN"}],"hgncRootFamilies":[{"name":"Pleckstrin homology domain containing (PLEKH)","href":"/api/1.0/gene_family/Pleckstrin+homology+domain+containing+%28PLEKH%29"}]}