{"symbol":"PRMT1","synonyms":["IR1B4","ANM1","HRMT1L2"],"name":"protein arginine methyltransferase 1","description":"This gene encodes a member of the protein arginine N-methyltransferase (PRMT) family. Post-translational modification of target proteins by PRMTs plays an important regulatory role in many biological processes, whereby PRMTs methylate arginine residues by transferring methyl groups from S-adenosyl-L-methionine to terminal guanidino nitrogen atoms. The encoded protein is a type I PRMT and is responsible for the majority of cellular arginine methylation activity. Increased expression of this gene may play a role in many types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2011]","ncbiEntrezGeneId":3276,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3276","proteins":[{"symbol":"ANM1_HUMAN","href":"/api/1.0/protein/ANM1_HUMAN"}],"hgncRootFamilies":[{"name":"Protein arginine methyltransferases (PRMT)","href":"/api/1.0/gene_family/Protein+arginine+methyltransferases+%28PRMT%29"}]}