{"symbol":"PRMT6","synonyms":["HRMT1L6"],"name":"protein arginine methyltransferase 6","description":"The protein encoded by this gene belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity. [provided by RefSeq, Sep 2011]","ncbiEntrezGeneId":55170,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/55170","proteins":[{"symbol":"ANM6_HUMAN","href":"/api/1.0/protein/ANM6_HUMAN"}],"hgncRootFamilies":[{"name":"Protein arginine methyltransferases (PRMT)","href":"/api/1.0/gene_family/Protein+arginine+methyltransferases+%28PRMT%29"}]}