{"symbol":"PROC","synonyms":["THPH4","APC","PROC1","THPH3"],"name":"protein C (inactivator of coagulation factors Va and VIIIa)","description":"This gene encodes a vitamin K-dependent plasma glycoprotein. The encoded protein is cleaved to its activated form by the thrombin-thrombomodulin complex. This activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII. Mutations in this gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.[provided by RefSeq, Dec 2009]","ncbiEntrezGeneId":5624,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5624","proteins":[{"symbol":"PROC_HUMAN","href":"/api/1.0/protein/PROC_HUMAN"}],"hgncRootFamilies":[{"name":"Endogenous ligands","href":"/api/1.0/gene_family/Endogenous+ligands"}]}