{"symbol":"PRPF19","synonyms":["NMP200","SNEV","PRP19","UBOX4","PSO4","HPSO4"],"name":"pre-mRNA processing factor 19","description":"Enables identical protein binding activity and ubiquitin-ubiquitin ligase activity. Involved in several processes, including DNA damage checkpoint signaling; mRNA splicing, via spliceosome; and protein K63-linked ubiquitination. Acts upstream of or within protein polyubiquitination. Located in cytoplasm; nuclear lumen; and site of double-strand break. Part of Prp19 complex and U2-type catalytic step 2 spliceosome. [provided by Alliance of Genome Resources, Mar 2025]","ncbiEntrezGeneId":27339,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/27339","proteins":[{"symbol":"PRP19_HUMAN","href":"/api/1.0/protein/PRP19_HUMAN"}],"hgncRootFamilies":[{"name":"U-box domain containing (UBOX)","href":"/api/1.0/gene_family/U-box+domain+containing+%28UBOX%29"},{"name":"WD repeat domain containing (WDR)","href":"/api/1.0/gene_family/WD+repeat+domain+containing+%28WDR%29"}]}