{"symbol":"PRPF8","synonyms":["RP13","PRPC8","HPRP8","SNRNP220"],"name":"pre-mRNA processing factor 8","description":"Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. This gene is a candidate gene for autosomal dominant retinitis pigmentosa. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":10594,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/10594","proteins":[{"symbol":"PRP8_HUMAN","href":"/api/1.0/protein/PRP8_HUMAN"}],"hgncRootFamilies":[]}