{"symbol":"PRSS8","synonyms":["CAP1","PROSTASIN"],"name":"protease, serine, 8","description":"This gene encodes a member of the peptidase S1 or chymotrypsin family of serine proteases. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate via a disulfide bond to form the heterodimeric enzyme. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. This protease exhibits trypsin-like substrate specificity, cleaving protein substrates at the carboxyl terminus of lysine or arginine residues. The encoded protease partially mediates proteolytic activation of the epithelial sodium channel, a regulator of sodium balance, and may also play a role in epithelial barrier formation. [provided by RefSeq, Feb 2016]","ncbiEntrezGeneId":5652,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5652","proteins":[{"symbol":"PRSS8_HUMAN","href":"/api/1.0/protein/PRSS8_HUMAN"}],"hgncRootFamilies":[{"name":"Proteases, serine (PRSS)","href":"/api/1.0/gene_family/Proteases%2C+serine+%28PRSS%29"}]}