{"symbol":"PSCA","synonyms":["PRO232"],"name":"prostate stem cell antigen","description":"This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]","ncbiEntrezGeneId":8000,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8000","proteins":[{"symbol":"PSCA_HUMAN","href":"/api/1.0/protein/PSCA_HUMAN"}],"hgncRootFamilies":[]}