{"symbol":"PSMA3","synonyms":["PSC3","HC8"],"name":"proteasome (prosome, macropain) subunit, alpha type, 3","description":"The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Two alternative transcripts encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":5684,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5684","proteins":[{"symbol":"PSA3_HUMAN","href":"/api/1.0/protein/PSA3_HUMAN"}],"hgncRootFamilies":[{"name":"Proteasome (prosome, macropain) subunits (PSM)","href":"/api/1.0/gene_family/Proteasome+%28prosome%2C+macropain%29+subunits+%28PSM%29"}]}