{"symbol":"PSMA7","synonyms":["C6","RC6-1","HSPC","HEL-S-276","XAPC7"],"name":"proteasome (prosome, macropain) subunit, alpha type, 7","description":"The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the peptidase T1A family that functions as a 20S core alpha subunit. The encoded protein interacts with the hepatitis B virus X protein and plays a role in regulating hepatitis C virus internal ribosome entry site (IRES) activity, an activity essential for viral replication. The encoded protein also plays a role in the cellular stress response by regulating hypoxia-inducible factor-1alpha. A pseudogene of this gene is located on the long arm of chromosome 9. [provided by RefSeq, Jul 2012]","ncbiEntrezGeneId":5688,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5688","proteins":[{"symbol":"PSA7_HUMAN","href":"/api/1.0/protein/PSA7_HUMAN"}],"hgncRootFamilies":[{"name":"Proteasome (prosome, macropain) subunits (PSM)","href":"/api/1.0/gene_family/Proteasome+%28prosome%2C+macropain%29+subunits+%28PSM%29"}]}