{"symbol":"PSMB10","synonyms":["LMP10","BETA2I","MECL1"],"name":"proteasome (prosome, macropain) subunit, beta type, 10","description":"The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Proteolytic processing is required to generate a mature subunit. Expression of this gene is induced by gamma interferon, and this gene product replaces catalytic subunit 2 (proteasome beta 7 subunit) in the immunoproteasome. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":5699,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5699","proteins":[{"symbol":"PSB10_HUMAN","href":"/api/1.0/protein/PSB10_HUMAN"}],"hgncRootFamilies":[{"name":"Proteasome (prosome, macropain) subunits (PSM)","href":"/api/1.0/gene_family/Proteasome+%28prosome%2C+macropain%29+subunits+%28PSM%29"}]}