{"symbol":"PSMD10","synonyms":["DJ889N15.2","p28","P28(GANK)"],"name":"proteasome (prosome, macropain) 26S subunit, non-ATPase, 10","description":"This gene encodes a subunit of the PA700/19S complex, which is the regulatory component of the 26S proteasome. The 26S proteosome complex is required for ubiquitin-dependent protein degradation. This protein is a non-ATPase subunit that may be involved in protein-protein interactions. Aberrant expression of this gene may paly a role in tumorigenesis. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20.[provided by RefSeq, Mar 2011]","ncbiEntrezGeneId":5716,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5716","proteins":[{"symbol":"PSD10_HUMAN","href":"/api/1.0/protein/PSD10_HUMAN"}],"hgncRootFamilies":[{"name":"Ankyrin repeat domain containing (ANKRD)","href":"/api/1.0/gene_family/Ankyrin+repeat+domain+containing+%28ANKRD%29"},{"name":"Proteasome (prosome, macropain) subunits (PSM)","href":"/api/1.0/gene_family/Proteasome+%28prosome%2C+macropain%29+subunits+%28PSM%29"}]}