{"symbol":"PSMD11","synonyms":["RPN6","P44.5"],"name":"proteasome (prosome, macropain) 26S subunit, non-ATPase, 11","description":"The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S9 family that functions as a non-ATPase subunit of the 19S regulator and is phosphorylated by AMP-activated protein kinase. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]","ncbiEntrezGeneId":5717,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5717","proteins":[{"symbol":"PSD11_HUMAN","href":"/api/1.0/protein/PSD11_HUMAN"}],"hgncRootFamilies":[{"name":"Proteasome (prosome, macropain) subunits (PSM)","href":"/api/1.0/gene_family/Proteasome+%28prosome%2C+macropain%29+subunits+%28PSM%29"}]}