{"symbol":"PTAFR","synonyms":["PAFR"],"name":"platelet-activating factor receptor","description":"This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]","ncbiEntrezGeneId":5724,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5724","proteins":[{"symbol":"PTAFR_HUMAN","href":"/api/1.0/protein/PTAFR_HUMAN"}],"hgncRootFamilies":[{"name":"G protein-coupled receptors","href":"/api/1.0/gene_family/G+protein-coupled+receptors"}]}