{"symbol":"PTGER1","synonyms":["EP1"],"name":"prostaglandin E receptor 1 (subtype EP1), 42kDa","description":"The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor\u0027s activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":5731,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5731","proteins":[{"symbol":"PE2R1_HUMAN","href":"/api/1.0/protein/PE2R1_HUMAN"}],"hgncRootFamilies":[{"name":"G protein-coupled receptors","href":"/api/1.0/gene_family/G+protein-coupled+receptors"}]}