{"symbol":"PTGER4","synonyms":["EP4R","EP4"],"name":"prostaglandin E receptor 4 (subtype EP4)","description":"The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":5734,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5734","proteins":[{"symbol":"PE2R4_HUMAN","href":"/api/1.0/protein/PE2R4_HUMAN"}],"hgncRootFamilies":[{"name":"G protein-coupled receptors","href":"/api/1.0/gene_family/G+protein-coupled+receptors"}]}