{"symbol":"PTPN11","synonyms":["SH-PTP2","METCDS","JMML","SH-PTP3","PTP-1D","BPTP3","PTP2C","SHP2","NS1"],"name":"protein tyrosine phosphatase, non-receptor type 11","description":"The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016]","ncbiEntrezGeneId":5781,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5781","proteins":[{"symbol":"PTN11_HUMAN","href":"/api/1.0/protein/PTN11_HUMAN"}],"hgncRootFamilies":[{"name":"SH2 domain containing","href":"/api/1.0/gene_family/SH2+domain+containing"},{"name":"Phosphatases","href":"/api/1.0/gene_family/Phosphatases"}]}