{"symbol":"PTPN18","synonyms":["BDP1","PTP-HSCF"],"name":"protein tyrosine phosphatase, non-receptor type 18 (brain-derived)","description":"The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]","ncbiEntrezGeneId":26469,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/26469","proteins":[{"symbol":"PTN18_HUMAN","href":"/api/1.0/protein/PTN18_HUMAN"}],"hgncRootFamilies":[{"name":"Phosphatases","href":"/api/1.0/gene_family/Phosphatases"}]}