{"symbol":"PTPN22","synonyms":["PTPN22.6","LYP2","PTPN22.5","LYP1","PTPN8"],"name":"protein tyrosine phosphatase, non-receptor type 22 (lymphoid)","description":"This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves\u0027 disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009]","ncbiEntrezGeneId":26191,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/26191","proteins":[{"symbol":"PTN22_HUMAN","href":"/api/1.0/protein/PTN22_HUMAN"}],"hgncRootFamilies":[{"name":"Phosphatases","href":"/api/1.0/gene_family/Phosphatases"}]}