{"symbol":"PTPN7","synonyms":["PTPNI","HEPTP","LC-PTP","BPTP-4","LPTP"],"name":"protein tyrosine phosphatase, non-receptor type 7","description":"The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This gene is preferentially expressed in a variety of hematopoietic cells, and is an early response gene in lymphokine stimulated cells. The non-catalytic N-terminus of this PTP can interact with MAP kinases and suppress the MAP kinase activities. This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function through dephosphorylating the molecules related to MAP kinase pathway. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2010]","ncbiEntrezGeneId":5778,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5778","proteins":[{"symbol":"PTN7_HUMAN","href":"/api/1.0/protein/PTN7_HUMAN"}],"hgncRootFamilies":[{"name":"Phosphatases","href":"/api/1.0/gene_family/Phosphatases"}]}