{"symbol":"PTPRG","synonyms":["HPTPG","RPTPG","R-PTP-GAMMA","PTPG"],"name":"protein tyrosine phosphatase, receptor type, G","description":"The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":5793,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5793","proteins":[{"symbol":"PTPRG_HUMAN","href":"/api/1.0/protein/PTPRG_HUMAN"}],"hgncRootFamilies":[{"name":"Fibronectin type III domain containing","href":"/api/1.0/gene_family/Fibronectin+type+III+domain+containing"},{"name":"Phosphatases","href":"/api/1.0/gene_family/Phosphatases"}]}