{"symbol":"PTPRM","synonyms":["RPTPM","HR-PTPU","RPTPU","R-PTP-MU","PTPRL1"],"name":"protein tyrosine phosphatase, receptor type, M","description":"The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":5797,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5797","proteins":[{"symbol":"PTPRM_HUMAN","href":"/api/1.0/protein/PTPRM_HUMAN"}],"hgncRootFamilies":[{"name":"Fibronectin type III domain containing","href":"/api/1.0/gene_family/Fibronectin+type+III+domain+containing"},{"name":"Phosphatases","href":"/api/1.0/gene_family/Phosphatases"},{"name":"Immunoglobulin superfamily domain containing","href":"/api/1.0/gene_family/Immunoglobulin+superfamily+domain+containing"}]}