{"symbol":"PTPRN","synonyms":["R-PTP-N","IA-2","IA2","IA-2/PTP","ICA512"],"name":"protein tyrosine phosphatase, receptor type, N","description":"The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]","ncbiEntrezGeneId":5798,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5798","proteins":[{"symbol":"PTPRN_HUMAN","href":"/api/1.0/protein/PTPRN_HUMAN"}],"hgncRootFamilies":[{"name":"Phosphatases","href":"/api/1.0/gene_family/Phosphatases"}]}