{"symbol":"PTPRN2","synonyms":["IA-2BETA","R-PTP-N2","IAR","PTPRP","ICAAR"],"name":"protein tyrosine phosphatase, receptor type, N polypeptide 2","description":"This gene encodes a protein with sequence similarity to receptor-like protein tyrosine phosphatases. However, tyrosine phosphatase activity has not been experimentally validated for this protein. Studies of the rat ortholog suggest that the encoded protein may instead function as a phosphatidylinositol phosphatase with the ability to dephosphorylate phosphatidylinositol 3-phosphate and phosphatidylinositol 4,5-diphosphate, and this function may be involved in the regulation of insulin secretion. This protein has been identified as an autoantigen in insulin-dependent diabetes mellitus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]","ncbiEntrezGeneId":5799,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5799","proteins":[{"symbol":"PTPR2_HUMAN","href":"/api/1.0/protein/PTPR2_HUMAN"}],"hgncRootFamilies":[{"name":"Phosphatases","href":"/api/1.0/gene_family/Phosphatases"}]}