{"symbol":"PUF60","synonyms":["VRJS","SIAHBP1","ROBPI"],"name":"poly-U binding splicing factor 60KDa","description":"This gene encodes a nucleic acid-binding protein that plays a role in a variety of nuclear processes, including pre-mRNA splicing and transcriptional regulation. The encoded protein forms a complex with the far upstream DNA element (FUSE) and FUSE-binding protein at the myelocytomatosis oncogene (MYC) promoter. This complex represses MYC transcription through the core-TFIIH basal transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]","ncbiEntrezGeneId":22827,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/22827","proteins":[{"symbol":"PUF60_HUMAN","href":"/api/1.0/protein/PUF60_HUMAN"}],"hgncRootFamilies":[{"name":"RNA binding motif containing (RBM)","href":"/api/1.0/gene_family/RNA+binding+motif+containing+%28RBM%29"}]}