{"symbol":"PVR","synonyms":["NECL-5","CD155","NECL5","HVED","TAGE4","PVS"],"name":"poliovirus receptor","description":"The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]","ncbiEntrezGeneId":5817,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5817","proteins":[{"symbol":"PVR_HUMAN","href":"/api/1.0/protein/PVR_HUMAN"}],"hgncRootFamilies":[{"name":"CD molecules (CD)","href":"/api/1.0/gene_family/CD+molecules+%28CD%29"},{"name":"Immunoglobulin superfamily domain containing","href":"/api/1.0/gene_family/Immunoglobulin+superfamily+domain+containing"}]}