{"symbol":"PVRL3","synonyms":["CD113","PPR3","NECTIN-3","NECTIN3","PRR3","CDW113","PVRR3"],"name":"poliovirus receptor-related 3","description":"This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]","ncbiEntrezGeneId":25945,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/25945","proteins":[{"symbol":"PVRL3_HUMAN","href":"/api/1.0/protein/PVRL3_HUMAN"}],"hgncRootFamilies":[{"name":"Immunoglobulin superfamily domain containing","href":"/api/1.0/gene_family/Immunoglobulin+superfamily+domain+containing"},{"name":"CD molecules (CD)","href":"/api/1.0/gene_family/CD+molecules+%28CD%29"}]}