{"symbol":"PZP","synonyms":["CPAMD6"],"name":"pregnancy-zone protein","description":"The protein encoded by this gene is highly expressed in late-pregnancy serum and is similar in structure to alpha-2-macroglobulin. The encoded protein, which acts as a homotetramer, inhibits the activity of all four classes of proteinases. This protein contains cleavage sites for several proteinases. Upon binding of a proteinase, the conformation of this protein changes to trap the proteinase, limiting its activity. This protein appears to be elevated in the sera of presymptomatic Alzheimer\u0027s disease patients. [provided by RefSeq, Dec 2016]","ncbiEntrezGeneId":5858,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5858","proteins":[{"symbol":"PZP_HUMAN","href":"/api/1.0/protein/PZP_HUMAN"}],"hgncRootFamilies":[]}