{"symbol":"RAD17","synonyms":["RAD24","CCYC","HRAD17","RAD17SP","R24L"],"name":"RAD17 homolog (S. pombe)","description":"The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Multiple alternatively spliced transcript variants of this gene, which encode four distinct protein isoforms, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified. [provided by RefSeq, Jul 2013]","ncbiEntrezGeneId":5884,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5884","proteins":[{"symbol":"RAD17_HUMAN","href":"/api/1.0/protein/RAD17_HUMAN"}],"hgncRootFamilies":[]}