{"symbol":"RAD18","synonyms":["RNF73"],"name":"RAD18 E3 ubiquitin protein ligase","description":"The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif.  Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":56852,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/56852","proteins":[{"symbol":"RAD18_HUMAN","href":"/api/1.0/protein/RAD18_HUMAN"}],"hgncRootFamilies":[{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}