{"symbol":"RAPH1","synonyms":["ALS2CR9","ALS2CR18","PREL-2","PREL2","RMO1","RALGDS/AF-6"],"name":"Ras association (RalGDS/AF-6) and pleckstrin homology domains 1","description":"This gene encodes a protein that belongs to the Mig10/Rap1-interacting adaptor molecule/Lamellipodin family of adapter proteins, which function in cell migration. Members of this family contain pleckstrin-homology domains, Ras-association domains, and proline-rich C-termini. The protein encoded by this gene regulates actin dynamics through interaction with Ena/Vasodilator proteins as well as direct binding to filamentous actin to regulate actin network assembly. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2016]","ncbiEntrezGeneId":65059,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/65059","proteins":[{"symbol":"RAPH1_HUMAN","href":"/api/1.0/protein/RAPH1_HUMAN"}],"hgncRootFamilies":[{"name":"Pleckstrin homology domain containing (PLEKH)","href":"/api/1.0/gene_family/Pleckstrin+homology+domain+containing+%28PLEKH%29"}]}