{"symbol":"RASA4","synonyms":["CAPRI","GAPL"],"name":"RAS p21 protein activator 4","description":"This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":10156,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/10156","proteins":[{"symbol":"RASL2_HUMAN","href":"/api/1.0/protein/RASL2_HUMAN"}],"hgncRootFamilies":[{"name":"C2 domain containing","href":"/api/1.0/gene_family/C2+domain+containing"}]}