{"symbol":"RASGRF2","synonyms":["RAS-GRF2"],"name":"Ras protein-specific guanine nucleotide-releasing factor 2","description":"RAS GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. This gene encodes a calcium-regulated nucleotide exchange factor activating both RAS and RAS-related protein, RAC1, through the exchange of bound GDP for GTP, thereby, coordinating the signaling of distinct mitogen-activated protein kinase pathways. [provided by RefSeq, Oct 2011]","ncbiEntrezGeneId":5924,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5924","proteins":[{"symbol":"RGRF2_HUMAN","href":"/api/1.0/protein/RGRF2_HUMAN"}],"hgncRootFamilies":[{"name":"Rho guanine nucleotide exchange factors (ARHGEF)","href":"/api/1.0/gene_family/Rho+guanine+nucleotide+exchange+factors+%28ARHGEF%29"},{"name":"Pleckstrin homology domain containing (PLEKH)","href":"/api/1.0/gene_family/Pleckstrin+homology+domain+containing+%28PLEKH%29"}]}