{"symbol":"RASGRP1","synonyms":["CALDAG-GEFII","RASGRP","V","HRASGRP1"],"name":"RAS guanyl releasing protein 1 (calcium and DAG-regulated)","description":"This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":10125,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/10125","proteins":[{"symbol":"GRP1_HUMAN","href":"/api/1.0/protein/GRP1_HUMAN"}],"hgncRootFamilies":[{"name":"EF-hand domain containing","href":"/api/1.0/gene_family/EF-hand+domain+containing"}]}