{"symbol":"RASGRP2","synonyms":["CALDAG-GEFI"],"name":"RAS guanyl releasing protein 2 (calcium and DAG-regulated)","description":"The protein encoded by this gene is a brain-enriched nucleotide exchanged factor that contains an N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be stimulated by calcium and diacylglycerol. Four alternatively spliced transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]","ncbiEntrezGeneId":10235,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/10235","proteins":[{"symbol":"GRP2_HUMAN","href":"/api/1.0/protein/GRP2_HUMAN"}],"hgncRootFamilies":[{"name":"EF-hand domain containing","href":"/api/1.0/gene_family/EF-hand+domain+containing"}]}