{"symbol":"RASSF8","synonyms":["C12orf2","HOJ1"],"name":"Ras association (RalGDS/AF-6) domain family (N-terminal) member 8","description":"This gene encodes a member of the Ras-assocation domain family (RASSF) of tumor suppressor proteins. This gene is essential for maintaining adherens junction function in epithelial cells and has a role in epithelial cell migration. It is a lung tumor suppressor gene candidate. A chromosomal translocation t(12;22)(p11.2;q13.3) leading to the fusion of this gene and the FBLN1 gene is found in a complex type of synpolydactyly. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]","ncbiEntrezGeneId":11228,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/11228","proteins":[{"symbol":"RASF8_HUMAN","href":"/api/1.0/protein/RASF8_HUMAN"}],"hgncRootFamilies":[]}