{"symbol":"RBBP8","synonyms":["CTIP","SAE2","JWDS","RIM","SCKL2"],"name":"retinoblastoma binding protein 8","description":"The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":5932,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5932","proteins":[{"symbol":"COM1_HUMAN","href":"/api/1.0/protein/COM1_HUMAN"}],"hgncRootFamilies":[]}