{"symbol":"RCHY1","synonyms":["PRO1996","CHIMP","ZNF363","RNF199","ZCHY","PIRH2","ARNIP"],"name":"ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase","description":"The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2013]","ncbiEntrezGeneId":25898,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/25898","proteins":[{"symbol":"ZN363_HUMAN","href":"/api/1.0/protein/ZN363_HUMAN"}],"hgncRootFamilies":[{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}