{"symbol":"RELA","synonyms":["NFKB3","p65"],"name":"v-rel avian reticuloendotheliosis viral oncogene homolog A","description":"NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]","ncbiEntrezGeneId":5970,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5970","proteins":[{"symbol":"TF65_HUMAN","href":"/api/1.0/protein/TF65_HUMAN"}],"hgncRootFamilies":[]}