{"symbol":"REST","synonyms":["DFNA27","GINGF5","NRSF","HGF5","XBR","WT6"],"name":"RE1-silencing transcription factor","description":"This gene was initially identified as a transcriptional repressor that represses neuronal genes in non-neuronal tissues. However, depending on the cellular context, this gene can act as either an oncogene or a tumor suppressor. The encoded protein is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regulator of neurogenesis. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2018]","ncbiEntrezGeneId":5978,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5978","proteins":[{"symbol":"REST_HUMAN","href":"/api/1.0/protein/REST_HUMAN"}],"hgncRootFamilies":[]}