{"symbol":"RFC4","synonyms":["RFC37"],"name":"replication factor C (activator 1) 4, 37kDa","description":"The elongation of primed DNA templates by DNA polymerase delta and DNA polymerase epsilon requires the accessory proteins proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). RFC, also named activator 1, is a protein complex consisting of five distinct subunits of 140, 40, 38, 37, and 36 kD. This gene encodes the 37 kD subunit. This subunit forms a core complex with the 36 and 40 kDa subunits. The core complex possesses DNA-dependent ATPase activity, which was found to be stimulated by PCNA in an in vitro system. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":5984,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5984","proteins":[{"symbol":"RFC4_HUMAN","href":"/api/1.0/protein/RFC4_HUMAN"}],"hgncRootFamilies":[{"name":"ATPases","href":"/api/1.0/gene_family/ATPases"}]}