{"symbol":"RFC5","synonyms":["RFC36"],"name":"replication factor C (activator 1) 5, 36.5kDa","description":"This gene encodes the smallest subunit of the replication factor C complex, which consists of five distinct subunits (140, 40, 38, 37, and 36 kDa) and is required for DNA replication. This subunit interacts with the C-terminal region of proliferating cell nuclear antigen and is required to open and load proliferating cell nuclear antigen onto DNA during S phase. It is a member of the AAA+ (ATPases associated with various cellular activities) ATPase family and forms a core complex with the 38 and 40 kDa subunits that possesses DNA-dependent ATPase activity. A related pseudogene has been identified on chromosome 9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]","ncbiEntrezGeneId":5985,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/5985","proteins":[{"symbol":"RFC5_HUMAN","href":"/api/1.0/protein/RFC5_HUMAN"}],"hgncRootFamilies":[{"name":"ATPases","href":"/api/1.0/gene_family/ATPases"}]}