{"symbol":"RFFL","synonyms":["RNF189","FRING","RIFIFYLIN","CARP2","RNF34L","CARP-2"],"name":"ring finger and FYVE-like domain containing E3 ubiquitin protein ligase","description":"Enables enzyme binding activity; p53 binding activity; and ubiquitin protein ligase activity. Involved in several processes, including negative regulation of cysteine-type endopeptidase activity; negative regulation of signal transduction; and protein K48-linked ubiquitination. Located in endosome membrane and plasma membrane. [provided by Alliance of Genome Resources, Mar 2025]","ncbiEntrezGeneId":117584,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/117584","proteins":[{"symbol":"RFFL_HUMAN","href":"/api/1.0/protein/RFFL_HUMAN"}],"hgncRootFamilies":[{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}